Symptoms:

In pregnancies less than 12 weeks

  • Spontaneous miscarriage before 12 weeks
  • High white blood cell count and/or Neutrophils, Monocytes (to be confirmed, a number of ladies have reported this)

In pregnancies 12+ weeks

  • Restricted fetal growth (severe) IUGR of an otherwise chromosomal normal fetus
  • Reduced amniotic fluid
  • Early warning of fetal growth restriction is a marked slowed down in growth
  • Abnormal Doppler studies showing indicating redistribution, intermittent absent flow and then eventually reverse end diagnosic flow

How can we check this diagnosis?

At this time the only way to check for this diagnosis is to have an assessment of the placenta following birth or miscarriage by a pathologist who will cite CHI through checking the placenta.
It is also important to ask the Pathologist to perform CD68 Immunostaining to check the levels of this particular cell. Sufferers will have elevated numbers of these cells in the placenta.

Sources:
Boyd and Redline (“Chronic histiocytic intervillositis: a placental lesion associated with recurrent reproductive loss” Human Pathology 2000 Nov 31(11):1389-96)

  • Am J Reprod ImmunolMicrobiol. 1987;15:85:91. Fribrinoid and trophoblastic necrosis with massive chronic intervillitis: An extreme variant of villitis of unknown etiology. Labarrere CA, Mullen E.
  • Pediatric and Development Pathology. 2006;9:234‐8. Co‐occurance of Massive Perivillous Fibrin Deposition and Chronic Intervillositis: Case Report. Weber MA, Nikkels PGJ et al.
  • Gynecol Obstet Biol Reprod (Paris). 2006;35(7):711‐9. Pronostic périnatal des grossesses compliquées d’intervillites chroniques placentaires: C. Rota, D. Carles, V. Schaeffer, F. Guyon, R. Saura, J. Horovitz Rota C. et al.
  • Placenta. 2010;31:1106‐10. Chronic intervillitis of the placenta: A systemic review. Contro E. et al.
  • Placenta. 2010;31:116‐9. Pathological charactéristic of a series of rare chronic hystiocytic intervillisitis of the placenta. Traeder J. et al.
  • Chronic histiocytic intervillositis of unknown etiology: Clinical features in a consecutive series of 69 cases: Marchaudon et. Al. Placenta 2011 Feb 32(2): 140-5).
  • Massive perivillous fibrin deposition and chronic intervillositis: frequently missed diagnoses with a high recurrence risk: MA Weber, PGJ Nikkels, KE Hamoen, JJ Duvekot, RR de Krijger

Arch Pathol Lab Med. 2012;136:657–659; doi: 10.5858/arpa.2011‐0328‐OA CD68 Immunostaining in the Evaluation of Chronic Histiocytic Intervillositis Debra S Heller MD Biol Reprod (Paris). 2006 Jun;35(4):396‐404. [Association des corticoïdes à l’aspirine pour la prévention des récidives de villite ou d’intervillite chroniques d’étiologie indéterminée: G. Boog, C. Le Vaillant, F. Alnoukari, F. Jossic, J. Barrier, J.‐Y. Muller ] http://chisupport.org/wp-content/uploads/2011/12/What-is-Chronic-Histioc…

Clinic Fees

  • Initial consultation – £350 (a deductible £100 deposit is required to secure this appointment)
  • Follow up consultation – £200
  • Immune tests- tests range from £150 to £700 each
  • Wellbeing tests- tests range from £60 to £155 each
  • Hormonal tests – tests range from £87 to £105 each
  • Non-invasive Fetal DNA testing- £450
  • Initial scan – £235
  • 3D saline scan – £450
  • HyFosy – £475
  • 3D saline scan + Hyfosy – £625
  • Early pregnancy scans (includes consultation) – £290
  • Nuchal scan (includes blood tests) – £360
  • Anomaly scan- £360
  • Growth scans package (28, 32 and 36 weeks) – £760

    Fetal Medicine scan packages are available on request.
  • Manual Vacuum Aspiration (MVA) – from £1893
  • Hysteroscopy – from £1300
  • Initial consultation –  £285
  • Nurse consultation – £200
  • IVF cycle-  From £3950 (excludes initial and nurse consultations medications,  pre-IVF investigation tests)

    IVF packages are available on request.
  • Initial consultation –  £285
  • Nurse consultation – £200
  • IUI cycle-  From £1200 (excludes initial and nurse consultations medications,  pre-IUI investigation tests)

    IUI packages are available on request
  • Sperm DNA Integrity- £490
  • Semen Analysis- £225
We accept insurance policies from BUPA at CRP Clinic.

Consultations are billed under Professor Shehata’s provider number: 04346007

Tests and investigations are billed under The Miscarriage Clinic’s provider number: 60012322

Please Note:
  • You are responsible for understanding your insurance coverage.
  • Contact your insurer before your initial consultation to verify coverage.
  • Check your policy for coverage limits and excess amounts.
  • Provide us with your insurance details, including membership/policy number and pre-authorization number.
  • Provide us with written confirmation (email or letter) from BUPA as to which tests/investigations they have agreed to cover.
  • If your policy doesn’t cover the full cost, you will be billed for the remaining balance.